Evolutional and Functional Analysis of T-box Regulon in Bacteria: Identification of New Genes Involved in Amino Acid Metabolism

Motivation: T-box antitermiantion is the most distributed mechanism of regulation of various amino acids in Gram-positive bacteria. Identification of the T-box regulon and a metabolic analysis of amino acid biosynthesis and transport is one of problems of comparative genetics, genomics and molecular biology. Results: Search for T-box elements and analysis of operon structures identified a large number of new candidate T-box regulated genes, mostly transporters, in Gram-positive bacteria. We assign amino acid specificity for a large number of candidate transporters as well as for other new amino acid related genes. Availability: The program is available by request to the author.